Wednesday, July 6, 2011

whole genome sequencing of E.coli in outbreak

Article in Genome Technology this month: (click to see it)

stresses the power of the genomics age. Check out this timeline:
- received sample on May 30
- completed genome sequencings on June 1
- Genomes assembled and submitted to NCBI by June 2

Findings
- that E. coli was a new strain
- that E. coli had many antibiotic resistance genes

concept of "Genomic epidemiology"discussed

Another part of this article looks at MRSA and genomic sequencing of 63 isolates - identifying 6700 SNP (single nucleotide polymorphisms) that accounted for the variability seen and related to the microevolutionary changes being seen.

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